Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

Author:

Connor Ashton A.1,Denroche Robert E.2,Jang Gun Ho3,Timms Lee4,Kalimuthu Sangeetha N.5,Selander Iris6,McPherson Treasa6,Wilson Gavin W.2,Chan-Seng-Yue Michelle A.5,Borozan Ivan7,Ferretti Vincent7,Grant Robert C.8,Lungu Ilinca M.9,Costello Eithne10,Greenhalf William10,Palmer Daniel10,Ghaneh Paula10,Neoptolemos John P.10,Buchler Markus11,Petersen Gloria12,Thayer Sarah13,Hollingsworth Michael A.14,Sherker Alana15,Durocher Daniel15,Dhani Neesha16,Hedley David16,Serra Stefano17,Pollett Aaron18,Roehrl Michael H. A.19,Bavi Prashant5,Bartlett John M. S.9,Cleary Sean20,Wilson Julie M.5,Alexandrov Ludmil B.21,Moore Malcolm16,Wouters Bradly G.22,McPherson John D.23,Notta Faiyaz5,Stein Lincoln D.24,Gallinger Steven1

Affiliation:

1. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada3Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada

2. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada4Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

3. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada4Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada5Department of Statistical Science, University of Toronto, Toronto, Ontario, Canada

4. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada6Genome Technologies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

5. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

6. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

7. Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

8. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

9. Transformative Pathology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

10. University of Liverpool, Liverpool, England

11. Heidelberg University Hospital, Heidelberg, Germany

12. Mayo Clinic, Rochester, Minnesota

13. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts

14. University of Nebraska Medical Centre, Omaha, Nebraska

15. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada13Molecular Genetics Department, University of Toronto, Toronto, Ontario, Canada

16. Division of Medical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

17. Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada

18. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada15Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

19. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada15Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada16Department of Pathology, University Health Network, Toronto, Ontario, Canada17Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada18BioSpecimen Sciences Program, University Health Network, Toronto, Ontario, Canada

20. PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada3Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, Ontario, Canada

21. Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico20Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico

22. Department of Pathology, University Health Network, Toronto, Ontario, Canada

23. Genome Technologies Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada17Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

24. Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada13Molecular Genetics Department, University of Toronto, Toronto, Ontario, Canada

Publisher

American Medical Association (AMA)

Subject

Oncology,Cancer Research

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