Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α

Author:

Aslibekyan Stella1,Agha Golareh2,Colicino Elena3,Do Anh N.14,Lahti Jari5,Ligthart Symen6,Marioni Riccardo E.78,Marzi Carola910,Mendelson Michael M.11121314,Tanaka Toshiko15,Wielscher Matthias16,Absher Devin M.17,Ferrucci Luigi15,Franco Oscar H.6,Gieger Christian91018,Grallert Harald910,Hernandez Dena19,Huan Tianxiao1114,Iurato Stella20,Joehanes Roby212223,Just Allan C.24,Kunze Sonja910,Lin Honghuang25,Liu Chunyu1114,Meigs James B.262728,van Meurs Joyce B. J.29,Moore Ann Zenobia30,Peters Annette163132,Prokisch Holger3334,Räikkönen Katri5,Rathmann Wolfgang35,Roden Michael363738,Schramm Katharina3334,Schwartz Joel D.39,Starr John M.4041,Uitterlinden André G.629,Vokonas Pantel42,Waldenberger Melanie910,Yao Chen1114,Zhi Degui43,Baccarelli Andrea A.3,Bandinelli Stefania44,Deary Ian J.414045,Dehghan Abbas16,Eriksson Johan46,Herder Christian1047,Jarvelin Marjo-Riitta164849,Levy Daniel1114,Arnett Donna K.50

Affiliation:

1. Department of Epidemiology, University of Alabama, Birmingham

2. The Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, New York

3. Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York

4. Now with Mount Sinai School of Medicine, New York, New York

5. Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland

6. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands

7. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom

8. Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom

9. Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany

10. German Center for Diabetes Research, Neuherberg, Germany

11. Framingham Heart Study, Framingham, Massachusetts

12. Boston University School of Medicine, Boston, Massachusetts

13. Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts

14. Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland

15. Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

16. Medical Research Council–Public Health England Centre for Environment and Health and Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

17. Hudson Alpha Institute for Biotechnology, Huntsville, Alabama

18. Institute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany

19. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland

20. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

21. Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, Massachusetts

22. Mathematical and Statistical Computing Laboratory, Center for Information Technology, Bethesda, Maryland

23. Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts

24. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York

25. Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts

26. Division of General Internal Medicine, Massachusetts General Hospital, Boston,

27. Department of Medicine, Harvard Medical School, Boston, Massachusetts

28. Program in Population and Medical Genetics, Broad Institute, Cambridge, Massachusetts

29. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands

30. Longitudinal Study Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

31. Institute of Epidemiology, Helmholtz Zentrum München German Research Centre for Environmental Health, Neuherberg, Germany

32. Deutsches Zentrum fur Herz-Kreislauf-Forschung (German Centre for Cardiovascular Research), Munich Heart Alliance, Munich, Germany

33. Institute of Human Genetics, Technical University Munich, Munich, Germany

34. Institute of Human Genetics, Helmholtz Zentrum Munich, Neuherberg, Germany

35. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany

36. Department of Endocrinology and Diabetology, Heinrich-Heine University, Düsseldorf, Germany

37. Institute for Clinical Diabetology, Düsseldorf, Germany

38. German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany

39. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts

40. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

41. Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom

42. Veterans Affairs Normative Aging Study, VA Boston Healthcare System, Boston, Massachusetts

43. School of Biomedical Informatics, University of Texas Health Science Center, Houston

44. Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy

45. Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom

46. Department of General Practice and Primary Health Care, Faculty of Medicine, University of Helsinki, Helsinki, Finland

47. German Diabetes Center, Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

48. Center for Life-Course Health Research, Northern Finland Cohort Center, Finland and Biocenter Oulu, University of Oulu, Oulu, Finland

49. Unit of Primary Care, Oulu University Hospital, Oulu, Finland

50. College of Public Health, University of Kentucky, Lexington

Publisher

American Medical Association (AMA)

Subject

Cardiology and Cardiovascular Medicine

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