1. Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland
2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow Scotland
3. Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, England4Medical Research Council Population Health Research Unit, University of Oxford, Oxford, England5National Institute for Health Research, Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, England