Anti-inflammatory properties of 5-hydroxypirimidine derivatives on the model of CFA-induced paw and ankle joint edema in rats-Reference-Cited by-同舟云学术

Anti-inflammatory properties of 5-hydroxypirimidine derivatives on the model of CFA-induced paw and ankle joint edema in rats

Published:2022-12-21 Issue:3 Volume: Page:33-36
ISSN:2686-8830
Container-title:Pharmacokinetics and Pharmacodynamics
language:
Short-container-title:Fk&Fd

Author:

Zhurikov R. V.¹^ORCID,Kovalenko L. P.¹^ORCID,Nikitin S. V.¹^ORCID

Affiliation:

1. FSBI «Zakusov Institute of Pharmacology»

Abstract

Anti-inflammatory potency of 5-hydroxypyrimidine derivatives SNK-411 (2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) and SNK-578 (hydrochloride 2-isobutyl-4,6-dimethyl-5-hydroxypirimidine) was evaluated on the model of complete Freund`s adjuvant (CFA)-induced exudative inflammation in experiment on 60 outbreed male rats weighing 180–200 g in comparison with prednisolone. Prednisolone, SNK-411 and SNK-578 were injected twice: in 24 and 2 hours in before the injection of CFA. Prednisolone was administered in dose of 10 mg/kg, SNK-411 in doses of 25 mg/kg and 40 mg/kg, SNK-578 in doses of 10 mg/kg and 25 mg/kg. Paw and ankle joint edema were registered 24 hours after subplantar injection of CFA in right hind foot. Prednisolone administration in dose of 10 mg/kg decreased paw and ankle joint edema, SNK-578 in dose of 25 mg/kg decreased exudative edema of the paw, SNK-411 in dose of 40 mg/kg decreased paw and ankle joint edema. Acquired data correlates with previously obtained results that 5-hydroxypirimidine derivatives have antiallergenic effect on the model of systemic anaphylaxis in experiment on guinea pigs.

Publisher

Publishing House OKI

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

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