Experimental pharmacokinetics of a new antiparkinsonian drug ADK-1113

Author:

Kravtsova O. Yu.1ORCID,Dvoryaninov D. A.1,Kolyvanov G. B.1ORCID,Litvin A. A.1ORCID,Gribakina O. G.1ORCID,Zherdev V. P.1ORCID

Affiliation:

1. FSBSI «Federal research center for innovator and emerging biomedical and pharmaceutical technologies»

Abstract

The pharmacokinetics of a new antiparkinsonian drug ADK-1113 after single intravenous and intragastric administrations in mice at doses of 10 and 20 mg/kg was studied. The absolute bioavailability was 10.1–16.3 % that indicates on potential possibility of preparing a dosage form for oral administration.

Publisher

Publishing House OKI

Reference9 articles.

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4. Kravtsova OYu, Dvoryaninov DA, Kolyvanov GB, et al. Quantification of a new antiparkinsonian agent ADK-1113 in mouse blood plasma by high performance liquid chromatography – tandem mass spectrometry. Exper. Clin. Pharmacol. 2024;87(2):6-12. (In Russ.). doi: 10/30906/0869-2092-2024-87-2-6-12.

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