Affiliation:
1. Pacific State Medical University
2. Institute of Automation and Control Processes
Abstract
Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals. Thioctic (Alpha-lipoic) Acid preparations are widely used in the preferential segment, their appointment is not always advisable due to the frequent use «off-label», which leads to ineffective treatment and unreasonable economic costs. Aim. Conduct an information search and filling the electronic service «Database of Clinical Trials of Medicines» for medicinal products containing Thioctic (Alpha-lipoic) Acid and provide author’s recommendations for rational pharmacotherapy. Materials and methods. The search and analysis of the results of clinical trials, systematic reviews and meta-analysis in international and Russian Databases — PubMed, EMBASE, Cochrane Collaboration, e-Library, «Cyberlininka» for medicines of metabolic action — Thioctic (Alpha-lipoic) Acid with their subsequent introduction into the Information Service «Database of Clinical Trials of Medicines». Results. Thioctic (Alpha-lipoic) Acid has a positive effect in the form of improvement of the clinical condition of patients and indicators of neurological scales in diabetic and alcoholic polyneuropathy without affecting the «hard» endpoints (decrease in the number of fatal complications and mortality). Conclusion. Service «Database of Clinical Trials of Medicines» for use by health care professionals and the author’s recommendations for the use of Thioctic (Alpha-lipoic) Acid can be used for the rational prescription of this medicines in Preferential Medicinal Providing.
Reference38 articles.
1. Tel'nova E.A. Programme DLO-ONLS — 10 let // Vestnik Roszdravnadzora. 2016;(5):143-147. [Telnova EA. Extensive Drug Coverage — ONLS Program is 10 years. Vestnik Roszdravnadzora. 2016;(5):143-147. (In Russ).]
2. Tel'nova E.A. Eksperiment, operedivshii vremya: o moskovskom eksperimente po izmeneniyu (uporyadocheniyu) oplaty za lekarstvennye sredstva, otpushchennye po l'gotnym retseptam // Remedium. 2019;(10):70- 75. [Telnova EA. Experiment ahead of time: about the Moscow experiment on preferential drug provision. Remedium. 2019;(10):70-75. (In Russ).] DOI: 10.21518/1561-5936-2019-10-70-75
3. Khabriev R.U., Sukhodolov A.P., Spasennikov B.A. i dr. Sistema prinyatiya reshenii v programme l'gotnogo lekarstvennogo obespecheniya // Izvestiya Baikal'skogo gosudarstvennogo universiteta. 2018;28(1):6-11. [Khabriev RU, Sukhodolov AP, Spasennikov BA et al. The decision-making system in the Program of Subsidized Pharmaceutical Provision. Izvestiya Baykal’skogo gosudarstvennogo universiteta = Bulletin of Baikal State University. 2018;28(1):6-11. (In Russ).] DOI: 10.17150/2500-2759.2018.28(1).6-11
4. Spasennikov B.A., Bezmel'nitsyna L.Yu. Problemy l'gotnogo lekarstvennogo obespecheniya // Aktual'nye problemy meditsiny i biologii. 2018;(3):58-62. [Spasennikov BA, Bezmelnitsyna LYu. Problems of preferential medicinal provision. Actual problems of medicine and biology. 2018;(3):58-62. (In Russ).] DOI: 10.24411/2587-4926-2018-10041
5. Shumatov V.B., Krukovich E.V., Chernaya I.P. i dr. Razvitie servisnogo menedzhmenta kak uslovie uspeshnoi modernizatsii sfery zdravookhraneniya // Tikhookeanskii meditsinskii zhurnal. 2015;(1):5-10. [Shumatov VB, Krukovich EV, Chernaya IP et al. Development of service management as a condition for the successful modernization of healthcare. Pacific Medical Journal. 2015;(1):5-10. (In Russ).]