Excess Leucine Intake Enhances Muscle Anabolic Signaling but Not Net Protein Anabolism in Young Men and Women

Author:

Glynn Erin L.1,Fry Christopher S.1,Drummond Micah J.213,Timmerman Kyle L.4,Dhanani Shaheen4,Volpi Elena45,Rasmussen Blake B.213

Affiliation:

1. Departments of Rehabilitation Science, University of Texas Medical Branch, Galveston, TX 77555

2. Departments of Physical Therapy, University of Texas Medical Branch, Galveston, TX 77555

3. Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX 77555

4. Departments of Internal Medicine, Divisions of University of Texas Medical Branch, Galveston, TX 77555

5. Departments of Geriatrics, University of Texas Medical Branch, Galveston, TX 77555

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference56 articles.

1. Flooding with L-[1–13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1–13C]valine;Smith;Am J Physiol.,1992

2. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein;Smith;Am J Physiol.,1998

3. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults;Volpi;Am J Clin Nutr.,2003

4. Amino-acid infusion increases the sensitivity of muscle protein-synthesis in vivo to insulin: effect of branched-chain amino-acids;Garlick;Biochem J.,1988

5. Regulation of cardiac and skeletal muscle protein synthesis by individual branched-chain amino acids in neonatal pigs;Escobar;Am J Physiol Endocrinol Metab.,2006

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