IMPACT OF GENETIC ANCESTRY ON THE DISTRIBUTION OF INTERFERON-λ4 RS12979860 POLYMORPHISM IN A GLOBAL POPULATION OF BUENOS AIRES, ARGENTINA
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Published:2022-12
Issue:2
Volume:33
Page:19-25
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ISSN:1852-6233
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Container-title:Journal of Basic and Applied Genetics
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language:
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Short-container-title:BAG
Author:
Mansilla F.C.1, Avena S.A.2, Dejean C.B.3, Turco C.S.4, Capozzo A.V.5
Affiliation:
1. Instituto de Virología e Innovaciones Tecnológicas (IVIT), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina. 2. Centro de Ciencias Naturales, Ambientales y Antropológicas (CCNAA), Universidad Maimónides, Buenos Aires, Argentina | Sección Antropología Biológica, Instituto de Ciencias Antropológicas (ICA), Facultad de Filosofía y Letras, Universidad de Buenos Aires, Buenos Aires, Argentina | Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina 3. Centro de Ciencias Naturales, Ambientales y Antropológicas (CCNAA), Universidad Maimónides, Buenos Aires, Argentina | Sección Antropología Biológica, Instituto de Ciencias Antropológicas (ICA), Facultad de Filosofía y Letras, Universidad de Buenos Aires, Buenos Aires, Argentina 4. Instituto de Virología e Innovaciones Tecnológicas (IVIT), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina 5. Instituto de Virología e Innovaciones Tecnológicas (IVIT), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) – Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina | Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Abstract
Human interferon-λ4 is a cytokine involved in early stages of antiviral responses. Strikingly, some allelic variants with diminished antiviral activity reduce the susceptibility to viral infections, thus they would have suffered a positive selection pressure throughout the evolutionary history of the genus Homo. An intronic variant within the IFNλ4 locus (rs12979860, T˃C) emerged as one of the main gene determinants of the response to HCV and other viruses. The rs12979860-C allele has a differential frequency in African, European and Native American populations, though South American data are scarce. Here we characterize for the first time the distribution of rs12979860 genotypes in a sample of the global population of Buenos Aires, Argentina, assessing its association with European, Native American and African parental components. The rs12979860 genotypes were determined by PCR-RFLP in DNA samples from donors of a blood banks of Buenos Aires (n=96), whose genetic individual ancestry (European, African or Native American) had been previously determined using molecular markers. The distribution of rs12979860-CC, CT and TT was 29.17%, 50.0% and 20.83%, respectively. A significant increase in the frequency of CC among donors with a strong European contribution and a greater impact of the Native American component among donors carrying the T allele were observed. Native American and European components were associated to the rs12979860 distribution in a sample of the global population of Buenos Aires, while no differences were directly attributable to the African ancestry. Considering interferon´s key role in antiviral responses, our results may contribute to both bioanthropological and immunogenetic studies associated with infectious diseases.
Key words: ancestry, Buenos Aires, IFNλ4 polymorphism, rs12979860 distribution.
Publisher
Sociedad Argentina de Genetica
Subject
Genetics (clinical),Genetics,Applied Microbiology and Biotechnology,Biotechnology
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