Abstract
SUMMARY
Using a modification of the granuloma pouch technique [Selye, 1953], it is demonstrated in rats that pretreatment with somatotrophic hormone (STH) augments the resistance of the adjacent skin to the necrotizing actions of the irritant, while cortisol has an opposite effect. The protective action of STH is abolished by simultaneous cortisol treatment.
It is concluded that, under suitable conditions, the ability of a chemical irritant to produce tissue necrosis can be altered at will by administering varying proportions of STH and cortisol.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
10 articles.
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