Abstract
SUMMARY
The effects of oestradiol-17β and progesterone on tissue regeneration in the rabbit's ear were investigated. One square centimetre of tissue was excised through the whole thickness of the ear under pentobarbitone anaesthesia, and the rate of replacement, in terms of increase in surface area of the regenerated tissue, was recorded at 7-day intervals up to 49 days. The hormones were administered by subcutaneous injection five times weekly during this period. In females, oestradiol in individual doses of 10 μg/3 kg body weight stimulated regenerative growth significantly; 100 μg had no effect, and 1000 μg was inhibitory. In males, injections of 10 μg oestradiol had no significant effect on regeneration, while 100 μg was inhibitory. Progesterone stimulated regeneration in females at a dose of 100 μg/3 kg body weight, and in both males and females at 1000 μg/3 kg. Tissues were examined at 49 days for changes produced by the experimental regimes, and the effects of 17-oxosteroid excretion during the experimental period were also measured. Liver damage was produced in females by oestradiol at the 1000 μg/3 kg level and in males at the 100 μg dose; in both groups it was accompanied by loss of weight. None of the other treatments had toxic effects. The regeneration blastemata of animals treated with progesterone were better vascularized than either those of the untreated controls or of animals treated with oestradiol. The possible significance of these results is discussed.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
7 articles.
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