1. 1Department of Molecular MedicineLa Sapienza University, 00161 Rome, Italy2Biomedical Science Park San Raffaele00128 Rome, Italy3Department of Health and Human ServicesCraniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA4Department of Genetics and Molecular BiologySapienza University of Rome, and Institute for Molecular Biology and Pathology, National Research Council (CNR), 00185 Rome, Italy