Prevention and treatment of neonatal lupus – a literature review-Reference-Cited by-同舟云学术

Prevention and treatment of neonatal lupus – a literature review

Published:2023-12-29 Issue:4 Volume:19 Page:290-294
ISSN:1734-1531
Container-title:Pediatria i Medycyna Rodzinna
language:
Short-container-title:Pediatr Med Rodz

Author:

Meliksetian Astrik¹^ORCID,Łopuszyńska Inga¹^ORCID,Kosecka Katarzyna¹^ORCID,Rudziński Patryk²^ORCID,Cieślik Aleksandra³^ORCID,Jargieło Anna⁴^ORCID,Kosieradzka Karolina³^ORCID,Adamowicz Dominik⁵^ORCID,Stańczyk Justyna⁶^ORCID,Wosińska Alicja⁷^ORCID,Pazik Dorota²^ORCID

Affiliation:

1. National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland

2. Independent Public Clinical Hospital Named After Prof. W. Orłowski of the Centre of Postgraduate Medical Education, Warsaw, Poland

3. Praski Hospital Sp. z o.o., Warsaw, Poland

4. Military Institute of Medicine – National Research Institute, Warsaw, Poland

5. University Clinical Centre, Medical University of Warsaw, Warsaw, Poland

6. Department of Early Arthritis, The Professor Eleonora Reicher National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland

7. Marshal Jozef Pilsudski Memorial Hospital in Płonsk, Płońsk, Poland

Abstract

Introduction: Neonatal lupus is a syndrome diagnosed in newborns whose mothers suffer from systemic connective tissue diseases with the presence of antibodies to Ro(SS-A) and La(SS-B) antigens. It most often manifests with skin lesions and cardiac conduction disturbances. The aim of the study was to analyse the risk factors for neonatal lupus based on a literature review. In addition, a number of recommendations were formulated for prevention and further management of affected mothers and their children. Materials and methods: We reviewed PubMed, ResearchGate and Google Scholar databases. A combination of keywords: lupus, pregnant, infant, heart block (according to Medical Subject Headings, MeSH) was used to identify relevant publications. Results: Given the lack of protocols for the diagnosis and treatment of neonatal lupus, ensuring that women can monitor foetal heart rate and quickly access obstetric care in the event of abnormal readings is an important aspect in the early diagnosis of the disease. The question of prevention and treatment remains open, but given the results of recent studies, recommendations on prevention and treatment of this syndrome have been designed. Conclusions: 1. Prophylactic maternal intake of hydroxychloroquine. 2. Weekly doppler ultrasound of the umbilical artery and echocardiography. 3. Planning delivery in specialised health care units. 4. Follow-up of the infant until 6–7 months of age.

Publisher

Medical Communications Sp. z.o.o.

Reference34 articles.

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