Blood CO Status Classification Using UV-VIS Spectroscopy and PSO-optimized 1D-CNN Model

Abstract

Rapid and effective blood carbon monoxide (CO) assessment is of great importance, especially in estimating CO-related morbidity and instituting effective preventive measures. The conventional detection methods using CO breath analysis lack sensitivity, while collecting biological fluid samples for CO level measurement is prone to external contamination and expensive for frequent use. This study proposes a one-dimensional convolutional neural network (1D-CNN) consisting of three stacked biconvolutional layers for binary classification of blood CO status using the diffuse reflectance spectroscopy technique. Iterative particle swarm optimization (PSO) has efficiently found the best network parameters to learn important features from the reflectance spectroscopy data. The findings showed good testing accuracy, specificity, and precision of 92.9%, 90%, and 89.7%, respectively, and a high sensitivity of 96.3% in determining abnormal blood CO among smokers using the proposed CNN network. Comparisons with eight existing machine learning and deep learning models revealed the proposed method’s effectiveness in classifying blood CO status while reducing computing time by 8–13 folds. The findings of this work provide new insights that are valuable for researchers in neural network design automation, healthcare management, and skin-related research, specifically for application in nondestructive evaluation and clinical decision-making.