Transient Retinal Effects of 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA, ASA404), an Antitumor Vascular-Disrupting Agent in Phase I Clinical Trials

Author:

Jameson Michael B.1,Sharp Dianne M.2,Sissingh Jennifer I.2,Hogg Christopher R.3,Thompson Paul I.4,McKeage Mark J.5,Jeffery Mark6,Waller Susan7,Acton Gary8,Green Colin8,Baguley Bruce C.9

Affiliation:

1. From the Regional Cancer Centre, Waikato Hospital, Hamilton, New Zealand; the

2. Departments of Ophthalmology and

3. Moorfields Eye Hospital, London, United Kingdom; the

4. Oncology, Auckland City Hospital, Auckland, New Zealand;

5. Department of Pharmacology and Clinical Pharmacology and the

6. Oncology Service, Christchurch Hospital, Christchurch, New Zealand; the

7. Drug Development Office, Cancer Research UK, London, United Kingdom; and

8. Antisoma Research Limited, London, United Kingdom.

9. Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand; the

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Subject

General Medicine

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