Exploring the therapeutic space around NAD+

Abstract

NAD+ is a central metabolite in the cell. Changes in NAD+ abundance and the activity of NAD+-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD+ levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD+ signaling pathway are being translated to the clinic.