1. Department of Pharmacology, B. Ceccarelli Center of Neurobiology, University of Milano, CNR Center of Molecular and Cellular Pharmacology and Department of Neurosciences, DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy; Department of Biomedical Sciences, CNR Center of Biomembranes, University of Padova, 35121 Padova, Italy