Affiliation:
1. Weill Institute for Cell and Molecular Biology, Cornell University 1 Department of Molecular Biology and Genetics, , Ithaca, NY, USA
Abstract
TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https://doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between inflammation and TDP-43 homeostasis.
Publisher
Rockefeller University Press