Toward a standard model for autophagosome biogenesis-Reference-Cited by-同舟云学术

Toward a standard model for autophagosome biogenesis

Published:2023-06-05 Issue:7 Volume:222 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Cook Annan S.I.¹²³,Hurley James H.¹²³⁴⁵^ORCID

Affiliation:

1. Graduate Group in Biophysics, University of California, Berkeley 1 , Berkeley, CA, USA

2. California Institute for Quantitative Biosciences, University of California, Berkeley 2 , Berkeley, CA, USA

3. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network 3 , Chevy Chase, MD, USA

4. Department of Molecular and Cell Biology, University of California, Berkeley 4 , Berkeley, CA, USA

5. Helen Wills Neuroscience Institute, University of California, Berkeley 5 , Berkeley, CA, USA

Abstract

Two papers in this issue resolve a long-standing obstacle to a “standard model” for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome component, while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle tracking to show that the dynamics of autophagy proteins are consistent with the concept.

Funder

Michael J. Fox Foundation for Parkinson's Research

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202304011/1453041/jcb_202304011.pdf

Reference14 articles.

1. Isolation and characterization of autophagy-defective mutants ofSaccharomyces cerevisiae

2. Autophagosome biogenesis comes out of the black box

3. Autophagy genes in biology and disease