Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?-Reference-Cited by-同舟云学术

Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?

Published:2023-01-19 Issue:2 Volume:222 Page:
ISSN:0021-9525
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Bianchi Enrica¹^ORCID,Wright Gavin J.¹^ORCID

Affiliation:

1. Department of Biology, Hull York Medical School, York Biomedical Research Institute, University of York 1 , York, UK

Abstract

The molecular mechanism of sperm–egg fusion is a long-standing mystery in reproduction. Brukman and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202207147) now provide evidence that the sperm surface protein IZUMO1, which is essential for mammalian fertilization, can induce membrane fusion in cultured cells.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202301035/1446729/jcb_202301035.pdf

Reference16 articles.

1. Sperm Meets Egg: The Genetics of Mammalian Fertilization

2. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

3. Mechanisms of fertilization elucidated by gene-manipulated animals

4. The hallmarks of cell-cell fusion

5. The challenges involved in elucidating the molecular basis of sperm–egg recognition in mammals and approaches to overcome them

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4. No evidence for a direct extracellular interaction between human Fc receptor–like 3 (MAIA) and the sperm ligand IZUMO1;Science Advances;2024-02-23

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