Affiliation:
1. Niigata University School of Medicine and Graduate School of Medical/Dental Sciences 1 Department of Neurochemistry and Molecular Cell Biology, , Niigata, Japan
Abstract
Phosphatidylserine levels and distribution are tightly controlled by dedicated enzymes at the ER and plasma membrane. Nakatsu and Kawasaki discuss new work by Aoki and colleagues (https://doi.org/10.1083/jcb.202212074), which reveals an acute reliance on phosphatidylserine synthesis in B cell lymphomas needed to prevent aberrant B cell receptor activation and ensuing apoptosis.
Funder
Japan Society for the Promotion of Science
Ono Medical Research Foundation
Takeda Science Foundation
Publisher
Rockefeller University Press