Affiliation:
1. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229
Abstract
The parasite responsible for malaria, Plasmodium falciparum, spends much of its life in the RBC under conditions of low cytosolic Ca2+. This poses an interesting problem for a parasite that depends on a Ca2+ signaling system to carry out its vital functions. This long standing puzzle has now been resolved by a clever series of experiments performed by Gazarini et al. (2003). Using advances in fluorescent Ca2+ imaging (Grynkiewics, G., M. Poenie, and R.Y. Tsien. 1985. J. Biol. Chem. 260:3440–3450; Hofer, A., and T. Machen. 1994. Am. J. Physiol. 267:G442–G451; Hofer, A.M., B. Landolfi, L. Debellis, T. Pozzan, and S. Curci. 1998. EMBO J. 17:1986–1995), these authors have elucidated the source of the Ca2+ gradient that allows the accumulation of intracellular Ca2+ within the parasite.
Publisher
Rockefeller University Press
Cited by
11 articles.
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