Morphological aspects of the normal versus pathological liver

Abstract

Introduction. Chronic liver diseases stimulate a degree of hepatocyte injury. This previously mentioned modifications, alters the known liver architecture and finally ends in cirrhosis. Liver pathology as cirrhosis develops after a long period of pathological alterations. In this iddea, inflammation is a great point that results in replacement of the healthy liver parenchyma with fibrotic tissue and regenerative nodules. In addition, progressive portal hypertension, systemic inflammation, and liver failure drive cirrhosis outcomes. The management of this liver pathology, is centred on the treatment of the causes and complications. Liver transplantation can be required in some cases.The aim of this article was to identify the best available evidences analyzing liver samples, normall and pathological.Material and methods. Were made permanent preparations and used two colors. Hematoxylin–Eosin and also Goldner – Szekely trichrome stains stain for observation at optical microscope with x10 and x40 lens magnification. Samples liver collected during necropsy, from healthy patients and from patients diagnosed with cirrhosis.Results and discussion. Normal liver with hepatocytes, Kiernann space, connective septa, observations using lens x10 and samples colored with Goldner Szekely trichrome stains. Beside, for comparisions, ill liver images, classic stain H&E. Inflammation is a great point that results in replacement of the healthy liver parenchyma with fibrotic tissue and regenerative nodules. In addition, progressive portal hypertension, systemic inflammation, and liver failure drive cirrhosis outcomes.Conclusions. Our contribution in the written text, is related to the impact of physical, psychological and physiological factors. All this previously mentioned factors, area great impact on the health-related quality of life of adult patients with liver cirrhosis. The management of this liver pathology, is centred on the treatment of the causes and complications. Liver transplantation can be required in some cases.