Building and breaking the gut barrier with bariatric surgery

Author:

Hankir Mohammed K.

Abstract

Bariatric surgery has been proposed to improve glycemic control in morbidly obese patients by stabilising the gut barrier and alleviating endotoxemia-induced insulin resistance. Here, recent studies are highlighted which reveal site-specific and at times opposing effects of bariatric surgery on the gut barrier. Further understanding the underlying mechanisms may not only inform the development of novel gut-based drugs for the initial treatment of type 2 diabetes, but possibly also assist in the management of its eventual relapse.

Publisher

Shared Science Publishers OG

Subject

Cancer Research,Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Medicine,Physiology

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