Inhibition of phosphoinositide‑3 kinases γ/δ ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model

Author:

Zhang Xian1,Dai Qianqian1,Shan Jiajia1,Zhang Shiyun1,Zhang Bin1,Liu Siyang1,Zhang Yixue1,Wang Ying1,Li Xiaojie1,Jin Xuguang1,Liang Dongmei1,Ding Jingjing2,Wang Yong3,Wen Yanting1

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China

2. Department of Respiratory Medicine and Jiangsu Key Laboratory of Molecular Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210003, P.R. China

3. State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Molecular Medicine, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210093, P.R. China

Publisher

Spandidos Publications

Subject

Cancer Research,Immunology and Microbiology (miscellaneous),General Medicine

Reference46 articles.

1. Granuloma formation in pulmonary sarcoidosis;Broos;Front Immunol,2013

2. ATS/ERS/WASOG statement on sarcoidosis. American thoracic society/european respiratory society/world association of sarcoidosis and other granulomatous disorders;Hunninghake;Sarcoidosis Vasc Diffuse Lung Dis,1999

3. Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis;Oswald-Richter;J Immunol,2013

4. Advances in understanding the immunopathology of sarcoidosis and implications on therapy;Cinetto;Expert Rev Clin Immunol,2016

5. Sarcoidosis;Iannuzzi;N Engl J Med,2007

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