1. Department of Biological Sciences, Laborat�rio de Biologia Molecular do C�ncer, UNIFESP, Universidade Federal de S�o Paulo, Campus Diadema, S�o Paulo 04039‑032, Brazil
2. Department of Biochemistry, Insitute of Pharmacology, Universidade Federal de S�o Paulo, Campus S�o Paulo, S�o Paulo 04044‑020, Brazil