Identifying Double Bond Positions in Phospholipids Using Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry Based on Oxygen Attachment Dissociation

Author:

Takahashi Hidenori1,Shimabukuro Yuji2,Asakawa Daiki3,Korenaga Akihito1,Yamada Masaki1,Iwamoto Shinichi1,Wada Motoi2,Tanaka Koichi1

Affiliation:

1. Shimadzu Corporation

2. Graduate School of Science and Engineering, Doshisha University

3. National Institute of Advanced Industrial Science and Technology (AIST), National Metrology Institute of Japan (NMIJ), Tsukuba Central 2

Publisher

The Mass Spectrometry Society of Japan

Subject

Spectroscopy,Instrumentation,Atomic and Molecular Physics, and Optics

Reference14 articles.

1. 1) W. Zhang, D. Zhang, Q. Chen, J. Wu, Z. Ouyang, Y. J. N. Xia. Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers. Nat. Commun. 10: 79, 2019.

2. 2) H. Tsugawa, M. Arita, M. Kanazawa, A. Ogiwara, T. Bamba, E. Fukusaki. MRMPROBS: A data assessment and metabolite identification tool for large-scale multiple reaction monitoring based widely targeted metabolomics. Anal. Chem. 85: 5191–5199, 2013.

3. 3) H. Takeda, Y. Izumi, M. Takahashi, T. Paxton, S. Tamura, T. Koike, Y. Yu, N. Kato, K. Nagase, M. Shiomi, T. Bamba. Widely-targeted quantitative lipidomics method by supercritical fluid chromatography triple quadrupole mass spectrometry. J. Lipid Res. 59: 1283–1293, 2018.

4. 4) J. L. Campbell, T. Baba. Near-complete structural characterization of phosphatidylcholines using electron impact excitation of ions from organics. Anal. Chem. 87: 5837–5845, 2015.

5. 5) M. C. Thomas, T. W. Mitchell, D. G. Harman, J. M. Deeley, J. R. Nealon, S. J. Blanksby. Ozone-induced dissociation: Elucidation of double bond position within mass-selected lipid ions. Anal. Chem. 80: 303–311, 2008.

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