The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment
Author:
Affiliation:
1. Department of Pathological Biochemistry, Kyoto Pharmaceutical University
Publisher
The Society for Free Radical Research Japan
Subject
Clinical Biochemistry,Nutrition and Dietetics,Medicine (miscellaneous)
Link
https://www.jstage.jst.go.jp/article/jcbn/71/1/71_21-155/_pdf
Reference58 articles.
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2. 2 Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet 2004; 5: 725–738.
3. 3 Simón AM, Schiapparelli L, Salazar-Colocho P, et al. Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels. Neurobiol Dis 2009; 33: 369–378.
4. 4 Dierssen M, Arqué G, McDonald J, et al. Behavioral characterization of a mouse model overexpressing DSCR1/RCAN1. PLoS One 2011; 6: e17010.
5. 5 Martin KR, Corlett A, Dubach D, et al. Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Hum Mol Genet 2012; 21: 3025–3041.
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