Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers

Author:

Obeidat Ma’en1ORCID,Nie Yunlong1,Fishbane Nick1,Li Xuan1,Bossé Yohan23ORCID,Joubert Philippe34,Nickle David C.5,Hao Ke6,Postma Dirkje S.7,Timens Wim8,Sze Marc A.1,Shannon Casey P.9,Hollander Zsuzsanna9,Ng Raymond T.9,McManus Bruce19,Miller Bruce E.10,Rennard Stephen1112,Spira Avrum13,Hackett Tillie-Louise114,Lam Wan15,Lam Stephen15,Faner Rosa16,Agusti Alvar16,Hogg James C.117,Sin Don D.118,Paré Peter D.118

Affiliation:

1. The University of British Columbia Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, British Columbia, Canada

2. Department of Molecular Medicine

3. Institut Universitaire de Cardiologie et de Pneumologie de Québec, and

4. Department of Molecular Biology, Medical Biochemistry, and Pathology, Laval University, Québec, Quebec, Canada

5. Merck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts

6. Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York

7. Department of Pulmonology, and

8. Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

9. Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, British Columbia, Canada

10. GlaxoSmithKline, King of Prussia, Pennsylvania

11. Division of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska

12. Clinical Discovery Unit, Early Clinical Development, AstraZeneca, Cambridge, United Kingdom

13. Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts

14. Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada

15. Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

16. Fundacio Clinic per a la Recerca Biomedica, Barcelona, Spain

17. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; and

18. Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Reference30 articles.

1. World Health Organization. The top 10 causes of death. Geneva, Switzerland: World Health Organization; 2014 [accessed 2016 Jun 1]. Available from: http://www.who.int/mediacentre/factsheets/fs310/en/index4.html

2. Chronic obstructive pulmonary disease and comorbidities

3. New Concepts in Chronic Obstructive Pulmonary Disease

4. The Pathology of Chronic Obstructive Pulmonary Disease

5. Emphysema Lung Tissue Gene Expression Profiling

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