Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect

Author:

Wong Sharon L.12ORCID,Awatade Nikhil T.12ORCID,Astore Miro A.3ORCID,Allan Katelin M.12ORCID,Carnell Michael J.4,Slapetova Iveta4,Chen Po-chia3ORCID,Setiadi Jeffry3ORCID,Pandzic Elvis4ORCID,Fawcett Laura K.125ORCID,Widger John R.125ORCID,Whan Renee M.4ORCID,Griffith Renate6ORCID,Ooi Chee Y.127ORCID,Kuyucak Serdar3ORCID,Jaffe Adam125ORCID,Waters Shafagh A.1285ORCID

Affiliation:

1. School of Women’s and Children’s Health, Faculty of Medicine and Health,

2. Molecular and Integrative Cystic Fibrosis Research Centre,

3. School of Physics, University of Sydney, Sydney, Australia; and

4. Katharina Gaus Light Microscopy Facility, Mark Wainwright Analytical Centre,

5. Department of Respiratory Medicine and

6. School of Chemistry, and

7. Department of Gastroenterology, Sydney Children’s Hospital, Randwick, Australia

8. School of Medical Sciences, Faculty of Medicine and Health, University of New South Wales Sydney, Sydney, Australia;

Funder

Australian National Health and Medical Research Council

Rebecca L. Cooper Foundation project

Cystic Fibrosis Australia–The David Millar Giles Innovation

Sydney Children Hospital Network Foundation

Luminesce Alliance research

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

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