Oxyresveratrol: A Potential Pharmacological Prospective Against Neurodegenerative Diseases

Abstract

Oxyresveratrol (OXY) is a polyphenolic compound found in various plants, including the heartwood of Artocarpus lakoocha, mulberry wood, mulberry twigs, and Smilacis chinae rhizome. Numerous reports have highlighted its pharmacological activities, such as antioxidant, anti-inflammatory, and neuroprotective effects. In this review, we specifically focus on the neuroprotective effects of oxyresveratrol in both in vitro and in vivo models. To conduct this review, we adopted a systematic approach and utilized search engines to explore online databases, covering publications from 2000 to 2021. We carefully analyzed the data and synthesized the findings into a comprehensive table and figure. Our review underscores the application of oxyresveratrol in the context of neurodegenerative diseases, with particular emphasis on conditions such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), ischemic strokes, and traumatic brain injury. The findings of our review suggest that oxyresveratrol holds significant promise as a natural compound for the prevention and management of neurodegenerative diseases. However, it is important to note that the clinical application of oxyresveratrol is still limited. Consequently, further research is warranted to explore the potential development of innovative health-promoting products utilizing oxyresveratrol, particularly in the context of protecting against neurodegenerative diseases in ageing populations.