Effect of <i>Cymbopogon schoenanthus</i> L. Spreng Extract on Gentamicin-Induced Renal Toxicity in Rats

Abstract

This study’s objective is to assess phytochemicals content and the protective effect of Cymbopogon schoenanthus hydroethanolic extract on gentamicin-induced renal toxicity in rats. Phytoconstituents were determined by using colorimetric tests. Three methods were used for the evaluation of antioxidant activity. The experiment used gentamicin in six different groups of albino rats. The biochemical analysis of current results displayed a significant reduction in blood urea and creatinine in groups intoxicated with gentamicin and administered two doses of the extract. While the concentration of total proteins and albumins has been increased. In addition, this plant decreased oxidative stress which was translated into a decrease in malondialdehyde content, and increased levels of antioxidant parameters, consequently an improvement in kidney functions. This study revealed a higher content of phenolic compounds, greater antioxidant activity and nephroprotective qualities of Cymbopogon shoenanthus extract for the first time.