Natural Polyphenols of Pomegranate and Black Tea Juices can Combat COVID-19 through their SARS-CoV-2 3C-like Protease-inhibitory Activity

Abstract

The SARS-CoV 3C-like protease-inhibitory activity of natural polyphenols of tea and their potential for the treatment of SARS was proved previously in the literature. Besides, the phenolic composition of pomegranate juice was evaluated by some researchers. Also, the recent studies proved that the novel COVID-19 acts via a similar mechanism with SARS. Based on these considerations, we strongly proposed that the black tea and pomegranate juice can be useful to combat COVID-19 through the inhibition of SARS-CoV-2 3C-like protease by their natural polyphenolic contaminates.