IFCC Interim Guidelines on Biochemical/Hematological Monitoring of COVID-19 Patients

Author:

Thompson Simon1,Bohn Mary Kathryn2,Mancini Nicasio3,Loh Tze Ping4,Wang Cheng-Bin5,Grimmler Matthias6,Yuen Kwok-Yung7,Mueller Robert8,Koch David9,Sethi Sunil4,Rawlinson William D.10,Clementi Massimo3,Erasmus Rajiv11,Leportier Marc12,Kwon Gye Cheol13,Menezes María Elizabeth14,Patru Maria-Magdalena15,Gramegna Maurizio16,Singh Krishna17,Najjar Osama18,Ferrari Maurizio3,Lippi Giuseppe19ORCID,Adeli Khosrow2,Horvath Andrea R.120

Affiliation:

1. Department of Clinical Chemistry , NSW Health Pathology, Prince of Wales Hospital , Sydney , NSW , Australia

2. Paediatric Laboratory Medicine, The Hospital for Sick Children, and Laboratory Medicine and Pathobiology , University of Toronto , Toronto , ON , Canada

3. University Vita-Salute San Raffaele , Milan , Italy

4. National University Health System , Singapore , Singapore

5. Chinese PLA General Hospital , Beijing , PR China

6. DiaSys Diagnostic Systems , Holzheim , Germany

7. University of Hong Kong , Hong Kong , PR China

8. Abbott Laboratories , Abbott Park , IL , USA

9. Emory University School of Medicine , Atlanta , GA , USA

10. Department of Virology, NSW Health Pathology, Prince of Wales Hospital , Sydney , NSW , Australia

11. University of Stellenbosch , Cape Town , Western Cape , Republic of Australia

12. Beckman Coulter Inc , Brea , CA , USA

13. Chungnam National University Hospital , Daejeon , Republic of South Korea

14. Secretaria de Saúde do Estado de Santa Catarina , Florianópolis , Brazil

15. Ortho Clinical Diagnostics , Raritan , NJ , USA

16. Sentinel CH. SpA , Milan , Italy

17. Siemens Healthcare USA , Malvern , PA , USA

18. Allied Health Professions Ministry of Health , Palestine , Palestine

19. University Hospital of Verona , Verona , Italy

20. Taskforce on COVID-19, International Federation of Clinical Chemistry (IFCC) , Milan , Italy

Abstract

Abstract Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. While these tests are already well established in most clinical laboratories, there is still debate regarding their clinical value in the management of COVID-19, particularly in pediatrics, as well as the value of composite clinical risk scores in COVID-19 prognostication. This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. These evidence-based recommendations will provide practical guidance to clinical laboratories worldwide, underscoring the contribution of biochemical and hematological testing to our collective pandemic response.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

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