MicroRNAs in the auditory system: tiny molecules with big impact-Reference-Cited by-同舟云学术

MicroRNAs in the auditory system: tiny molecules with big impact

Published:2022-10-07 Issue:4 Volume:28 Page:211-221
ISSN:0947-0875
Container-title:Neuroforum
language:en
Short-container-title:

Author:

Ebbers Lena¹,Altaf Faiza¹,Nothwang Hans Gerd¹

Affiliation:

1. Division of Neurogenetics, Department of Neuroscience , School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg , 26129 Oldenburg , Germany

Abstract

Abstract “Blindness separates from things; deafness separates from people.” This quote attributed to the deaf-blind author and activist Helen Keller (1880–1968) indicates the importance of proper hearing for social interaction in our society which is largely driven by acoustic communication. A major cause for auditory dysfunction lies in our genome with currently more than 100 genes linked to hearing loss. One example is the microRNA gene Mir-96 of the microRNA-183 family. MicroRNAs are small regulatory RNAs involved in the finetuning of gene expression. Analyses of transgenic mouse models established this microRNA family as a major regulator for the function of the inner ear as well as synaptic transmission in the auditory brainstem. The microRNA-183 family might therefore play an important role in coordinating the development of the peripheral and central auditory system and their specializations.

Publisher

Walter de Gruyter GmbH

Subject

Neurology (clinical),Neurology

Link

https://www.degruyter.com/document/doi/10.1515/nf-2022-0016/pdf

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