Stability analysis of delay integro-differential equations of HIV-1 infection model

Abstract

AbstractIn this paper, the analysis of an HIV-1 epidemic model is presented by incorporating a distributed intracellular delay. The delay term represents the latent period between the time that the target cells are contacted by the virus and the time the virions penetrated into the cells. To understand the analysis of our proposed model, the Rouths–Hurwiz criterion and general theory of delay differential equations are used. It is shown that the infection free equilibrium and the chronic-infection equilibrium are locally as well as globally asymptotically stable, under some conditions on the basic reproductive number {R_{0}}. Furthermore, the obtained results show that the value of {R_{0}} can be decreased by increasing the delay. Therefore, any drugs that can prolong the latent period will help to control the HIV-1 infection.