High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection-Reference-Cited by-同舟云学术

High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection

Published:2018-01-27 Issue:1 Volume:55 Page:12-20
ISSN:1336-9083
Container-title:Helminthologia
language:en
Short-container-title:

Author:

Okamoto M.¹,Ito R.¹,Taira K.²,Ikeda T.¹

Affiliation:

1. Laboratory of Veterinary Immunology , Department of Veterinary Medicine, School of Veterinary Medicine , Azabu University , 1-17-71 Fuchinobe, Chuo-ku, Sagamihara , Kanagawa 252-5201 , Japan

2. Laboratory of Parasitology , Department of Veterinary Medicine, School of Veterinary Medicine , Azabu University , 1-17-71 Fuchinobe, Chuo-ku, Sagamihara , Kanagawa 252-5201 , Japan

Abstract

Summary The novel WBN/Kob-Leprfa (fa/fa) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. However, inflammatory cytokine profiles and their correlations with T2DM development/progression in fa/fa rats have not been studied. In this study, we found that the fa/fa rats had considerably high plasma levels of interleukin (IL)-1α. Abundant cecal IL-1α mRNA expression and cecal inflammation with infiltrating IL-1α-producing macrophages was observed in fa/fa rats. Bone marrow derived macrophages from fa/fa rats expressed high levels of IL-1α upon lipopolysaccharide stimulation. Furthermore, Syphacia muris infection, which delays the onset of T2DM, reduced both plasma and cecal IL-1α levels in fa/fa rats. These results suggest that macrophage infiltration and IL-1α secretion comprise an important part of T2DM development and that S. muris infection inhibits pro-inflammatory cytokine expression in fa/fa rats.

Publisher

Walter de Gruyter GmbH

Subject

Animal Science and Zoology,Parasitology

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