Affiliation:
1. 1Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Abstract
AbstractBackground: An increase in the EEG upper/low a power ratio has been associated with mild cognitive impairment
(MCI) due to Alzheimer’s disease (AD) and to the atrophy of temporoparietal brain areas. Subjects with a higher
α3/α2 frequency power ratio showed lower brain perfusion than in the low α3/α2 group. The two groups show
significantly different hippocampal volumes and correlation with q frequency activity. Methods: Seventy-four
adult subjects with MCI underwent clinical and neuropsychological evaluation, electroencephalogram (EEG)
recording, and high resolution 3D magnetic resonance imaging (MRI). Twenty-seven of them underwent EEG
recording and perfusion single-photon emission computed tomography (SPECT) evaluation. The α3/α2 power
ratio and cortical thickness were computed for each subject. The difference in cortical thickness between the
groups was estimated. Results: In the higher upper/low a group, memory impairment was more pronounced
in both the MRI group and the SPECT MCI groups. An increase in the production of q oscillations was associated
with greater interhemisperic coupling between temporal areas. It also correlated with greater cortical atrophy
and lower perfusional rate in the temporoparietal cortex. Conclusion: High EEG upper/low α power ratio was
associated with cortical thinning and lower perfusion in temporoparietal areas. Moreover, both atrophy and
lower perfusion rate significantly correlated with memory impairment in MCI subjects. Therefore, the increase
in the EEG upper/low α frequency power ratio could be useful in identifying individuals at risk for progression to
AD dementia in a clinical context.
Cited by
8 articles.
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