Vanadocen-dichlorid - ein weiteres Antitumor-Agens aus der Metallocenreihe / Vanadocene Dichloride - Another Antitumor Agent from the Metallocene Series

Abstract

Abstract The antitumor activity of vanadocene dichloride is investigated against Ehrlich ascites tumor in CFi mice. The application of 80 or 90 mg/kg 24 h after transplantation achieves 100% tumor inhibition until day 30. On treatment with higher doses death of an increasing number of animals is caused by substance toxicity. The results of this study indicate that vanadocene dichloride exhibits antineoplastic properties similar to those found for titanocene dichloride and cis-dichlorodiammine-platinum(II).