Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer-Reference-Cited by-同舟云学术

Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer

Published:2016-07-26 Issue:3-4 Volume:27 Page:59-65
ISSN:2195-4720
Container-title:Pteridines
language:en
Short-container-title:

Author:

Melichar Bohuslav¹²³,Študentová Hana¹,Vitásková Denisa¹,Šrámek Vlastislav¹,Kujovská Krčmová Lenka⁴⁵,Pešková Eliška²,Solichová Dagmar⁴,Kalábová Hana¹,Ryška Aleš⁶,Hrůzová Klára¹,Havlík Roman⁷

Affiliation:

1. Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech Republic

2. Fourth Department of Medicine, Charles University Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic

3. Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Hněvotínská 5, 779 00 Olomouc, Czech Republic

4. Third Department of Medicine, Charles University Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic

5. Department of Analytical Chemistry, Charles University School of Pharmacy, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

6. The Fingerland Department of Pathology, Charles University Medical School and Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic

7. Department of Surgery, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech Republic

Abstract

Abstract The immune response crucially determines the survival of patients with malignant tumors including breast carcinoma. The aim of the present study was to evaluate retrospectively an association of peripheral blood cell count (PBC)-derived ratios and urinary neopterin concentration with prognosis in breast cancer patients. Urinary neopterin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were retrospectively analyzed in a cohort of 474 breast cancer patients. NLR and PLR correlated positively with each other and negatively with LMR, but no correlation between neopterin concentrations and PBC-derived ratios was observed. Increased urinary neopterin concentration was a significant predictor of poor survival in patients with active disease, but PLR, NLR or LMR were not significantly associated with survival in multivariate analysis. In conclusion, increased urinary neopterin was a significant predictor of poor survival in patients with breast cancer and active disease.

Funder

Ministry of Health

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Medicine,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/pterid-2016-0001/pdf

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