Affiliation:
1. Department of Anatomy and Embryology, University of Amsterdam
Abstract
Experiments were designed to investigate the low-dose side of the so-called dose-effect relation of mercuric chloride on the proliferation of a murine lymphoblastic cell strain (MB VIa). Three concentration ranges, from 0.9 × 10-5 м to 0.9 × 10-18 м, from 0.9 × 10-12 м to 0.9 × 10-25 м , and from 0.9 × 10-15 м to 0.9 x 10-21 м, in which the concentration decreased stepwise by a factor 10, were studied in 61, 74 and 58 experimental repetitions, respectively.
In the first range, the concentrations 0.9 × 10-5 M and 0.9 x 10-6 м HgCl2 proved to be definitely toxic as was expected. However, also 0.9 × 10-16 м and 0.9 × 10-17 м appeared to be growth-inhibiting, the latter results being confirmed in the second and the third concentration ranges. These differences in cell growth were statistically significant.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
11 articles.
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