Serum asprosin levels in patients with retinopathy of prematurity-Reference-Cited by-同舟云学术

Serum asprosin levels in patients with retinopathy of prematurity

Published:2022-09-06 Issue:6 Volume:47 Page:749-755
ISSN:1303-829X
Container-title:Turkish Journal of Biochemistry
language:en
Short-container-title:

Author:

Yardim Meltem¹^ORCID,Celik Fatih²^ORCID,Oruc Yavuz²^ORCID,Kayalp Damla³^ORCID,Beyazyildiz Ozlem⁴^ORCID,Yesilirmak Didem Cemile⁵^ORCID,Ulas Mustafa⁶^ORCID,Aydin Suleyman⁷^ORCID

Affiliation:

1. Department of Medical Biochemistry , Yerkoy State Hospital , Yozgat , Turkey

2. Department of Ophthalmology , Fethi Sekin City Hospital, Health Science University , Elazig , Turkey

3. Department of Medical Biochemistry , Yozgat City Hospital , Yozgat , Turkey

4. Department of Ophthalmology , Samsun Training and Research Hospital, Health Science University , Samsun , Turkey

5. Department of Neonatology , Istinye University , Istanbul , Turkey

6. Department of Physiology, Faculty of Medicine , Firat University , Elazig , Turkey

7. Department of Medical Biochemistry and Clinical Biochemistry, (Firat Hormones Research Group), Faculty of Medicine , Firat University , Elazig , Turkey

Abstract

Abstract Objectives This study was aimed to investigate the diagnostic values of serum levels of asprosin and neutrophil gelatinase-associated lipocalin (NGAL) in Retinopathy of prematurity (ROP) and to assess the role of these biomarkers on the development and progression of the condition. Methods This study was carried out from April 2020 to February 2021 in the department of ophthalmology of a tertiary hospital in Turkey. Thirty patients diagnosed with ROP and 30 healthy newborns were included the study. Serum NGAL and asprosin levels were determined via ELISA. Results The median serum NGAL levels were found to be similar between the ROP group and the control group (p=0.595). Median asprosin levels were significantly higher in patients diagnosed with ROP [46.58 (12.70–142.28) ng/mL] compared to healthy subjects [13.05 (10.92–17.73) ng/mL] (p=0.001). The optimal cut-off value of asprosin by ROC analysis was 30 ng/mL (AUC: 0.754, p=0.001) for diagnosing ROP. Serum asprosin levels were positively correlated with serum ALP levels and inversely correlated with gestational week, uric acid and AST values (all, p<0.005). Conclusions Our results demonstrated that asprosin, but not NGAL, could be a biomarker for the diagnosis of ROP.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/tjb-2022-0019/pdf

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