Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma-Reference-Cited by-同舟云学术

Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma

Published:2024-01-01 Issue:1 Volume:19 Page:
ISSN:2391-5412
Container-title:Open Life Sciences
language:en
Short-container-title:

Author:

Shao Weilin¹,Feng Yan¹,Huang Jin¹,Li Tingyu²,Gao Shengguai²,Yang Yihao¹,Li Dongqi¹,Yang Zuozhang¹,Yao Zhihong³⁴

Affiliation:

1. Bone and Soft Tissue Tumours Research Centre of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center) , Kunming , Yunnan, 650118 , China

2. Clinical Oncology Institute, Kunming Medical University , Kunming , Yunnan, 650500 , China

3. Bone and Soft Tissue Tumours Research Centre of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center) , No. 519 Kunzhou Road, Xishan District , Kunming , Yunnan, 650118 , China

4. Department of Cancer Research Institute, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center) , No. 519 Kunzhou Road, Xishan District , Kunming , Yunnan, 650118 , China

Abstract

Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, and is characterized by high heterogeneity, high malignancy, easy metastasis, and poor prognosis. Recurrence, metastasis, and multidrug resistance are the main problems that limit the therapeutic effect and prognosis of OS. PI3K/AKT/mTOR signaling pathway is often abnormally activated in OS tissues and cells, which promotes the rapid development, metastasis, and drug sensitivity of OS. Emerging evidence has revealed new insights into tumorigenesis through the interaction between the PI3K/AKT/mTOR pathway and non-coding RNAs (ncRNAs). Therefore, we reviewed the interactions between the PI3K/AKT/mTOR pathway and ncRNAs and their implication in OS. These interactions have the potential to serve as cancer biomarkers and therapeutic targets in clinical applications.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/biol-2022-0936/pdf

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