Antibacterial Diterpenoids from Astragalus brachystachys-Reference-Cited by-同舟云学术

Antibacterial Diterpenoids from Astragalus brachystachys

Published:2002-12-01 Issue:11-12 Volume:57 Page:1016-1021
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Jassbi Amir Reza¹,Zamanizadehnajari Simin¹,Azar Parviz Aberoomand²,Tahar Satoshi¹

Affiliation:

1. Laboratory of Ecological Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan.

2. Department of Chemistry, Science and Research Campus, Islamic Azad University, Poonak, Tehran, Iran

Abstract

Antibacterial bioassay guided fractionation of acetone extracts of Astragalus brachystachys resulted in isolation of sclareol and two related labdane-type diterpenoids, 14R-epoxysclareol and 6β-hydroxysclareol. The antibacterial activity of the isolated compounds was measured and it was deduced that the epoxidation at the double bond of sclareol or hydroxylation at C-6 decreased the activity of the resulting compounds. Salvigenin (5-hydroxy-4′,6,7-trimethoxyflavone) was also separated from this plant for the first time.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2002-11-1211/pdf

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