Construction of fluorescence system of felodipine–tetracyanovinyl–2,2′-bipyridine complex

Author:

Lang Yan1,Zeng Yuanjun2,Zhang Chunbin2,Lv Kuilin3

Affiliation:

1. Department of Rehabilitation Therapy, Wuyi University , Nanping 354301, Fujian Province , China

2. Department of Medical Technology, Zhang Zhou Health Vocational College/Collaborative Innovation Center for Translation Medical Testing and Application Technology , Zhangzhou 363000, Fujian Province , China

3. State Key Laboratory of Green Building Materials, China State Building Materials Research Institute Co., Ltd , Beijing 100000 , China

Abstract

Abstract Felodipine (FEL)–tetracyanoethylene (TCNE)–2,2′-bipyridine (Bpy) complex was prepared with FEL, TCNE–Bpy and characterized by fluorescence, ultraviolet, and infrared. By exploring the concentration and dosage of Bpy, it was found that 1 mL 2 × 10−3 mol‧L−1 of Bpy had the best effect. The sequence of reagent addition was determined to be followed by FEL, then by TCNE, and then followed by Bpy. The concentration of FEL was 2.5 × 10−4 to 9.0 × 10−3 mol‧L−1, which had a good linear relationship with fluorescence intensity. The compound had good accuracy, precision, and specificity, and could be used for the determination of phelodipine content in FEL sustained-release tablets.

Publisher

Walter de Gruyter GmbH

Subject

Health, Toxicology and Mutagenesis,Industrial and Manufacturing Engineering,Fuel Technology,Renewable Energy, Sustainability and the Environment,General Chemical Engineering,Environmental Chemistry

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