Author:
Sumalatha Kodandaram,Gowda Mohan,Meenakshisundaram Sreepriya
Abstract
AbstractBackgroundEmbelin is a benzoquinone reported to possess anticancer activity in severalMethodsThe effect of embelin (35 µg/mL for 24 h) on cell proliferation was assessed by Sulforhodamine B assay and bromodeoxyuridine incorporation test, antiinvasive effect by Boyden chamber assay and scratch assay. Proapoptotic effects of embelin were determined by studies on DNA fragmentation, annexin V-FITC labeling, TUNEL assay, COMET assay and assay of caspase-3 activity. Influence of embelin on the expression of genes regulating apoptosis (caspase 3 and 9, Bcl-2, Bax, cytochromeResultsResults implicated that embelin treatment inhibited proliferation (ICConclusionsTo conclude, embelin treatment could be a promising strategy for the chemotherapy of colon cancer.
Subject
Complementary and alternative medicine
Cited by
15 articles.
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