New Anthraquinones from a Marine Streptomyces sp. – Isolation, Structure Determination and Biological Activities

Author:

Poumale Hervé M. P.12,Ngadjui Bonaventure T.3,Helmke Elisabeth4,Laatscha Hartmut1

Affiliation:

1. Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstraße 2, D-37077 Göttingen, Germany

2. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Younde, Cameroon

3. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon

4. Alfred-Wegener-Institute for Polar and Marine Research, Am Handelshafen 12, D-27570 Bremerhaven, Germany

Abstract

Two new anthraquinones were isolated from the marine Streptomyces sp. B8000, in addition to the known metabolites 3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid (1a), indole-3- carboxylic acid, 2-desoxythymidin, indole-3-acetic acid methyl ester, N-acetyltyramine, and nicotinic acid. The structures of the new compounds were established as 8-hydroxy-3-methoxy-1- propylanthraquinone (2a) and 3,8-dihydroxy-1-propylanthraquinone (2c) on the basis of extensive spectroscopic analyses. Some derivatives were prepared and their biological activities were studied.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

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