Author:
Hu Jiamiao,Christian Mark
Abstract
AbstractAdipose tissue has been historically classified into anabolic white adipose tissue (WAT) and catabolic brown adipose tissue (BAT). Recent studies have revealed the plasticity of WAT, where white adipocytes can be induced into ‘brown-like’ heat-producing adipocytes (BRITE or beige adipocytes). Recruiting and activating BRITE adipocytes in WAT (so-called ‘browning’) is believed to provide new avenues for the treatment of obesity-related diseases. A number of hormonal factors have been found to regulate BRITE adipose development and activity through autocrine, paracrine and systemic mechanisms. In this mini-review we will discuss the impact of these factors on the browning process, especially those hormonal factors identified with direct effects on white adipocytes.
Subject
Endocrinology,Molecular Biology,General Medicine,Endocrinology, Diabetes and Metabolism
Reference246 articles.
1. Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody;J Pharmacol Exp Ther,2013
2. Systemic CCK increases brown adipose tissue sympathetic nerve activity;FASEB J,2013
3. Human BAT possesses molecular signatures that resemble beige/brite cells;PLoS One,2012
4. Effects of cholecystokinin on sympathetic activity to interscapular brown adipose tissue;Brain Res,1992
5. Central oxytocin and food intake: focus on macronutrient-driven reward;Front Endocrinol,2015
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