Cephradine drug release using electrospun chitosan nanofibers incorporated with halloysite nanoclay
Author:
Naz Mahwish1, Rizwan Muhammad2, Jabeen Sehrish3, Ghaffar Abdul1, Islam Atif3, Gull Nafisa3, Rasool Atta4, Khan Rafi Ullah3, Alshawwa Samar Z.5, Iqbal Munawar2
Affiliation:
1. Department of Chemistry , University of Engineering and Technology , Lahore , Pakistan 2. Department of Chemistry , The University of Lahore , Lahore , Pakistan 3. Institute of Polymer and Textile Engineering , University of the Punjab , Lahore , Pakistan 4. School of Chemistry , University of the Punjab , Lahore , Pakistan 5. Department of Pharmaceutical Sciences , College of Pharmacy, Princess Nourah bint Abdulrahman University , Riyadh , Saudi Arabia
Abstract
Abstract
The chitosan/polyvinyl alcohol/halloysite nanoclay (CS/PVA/HNC) loaded with cephradine drug electrospun nanofibers (NFs) were fabricated and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) techniques. FTIR analysis confirmed the hydrogen bonding between the polymer chain and the developed siloxane linkages. SEM analysis revealed the formation of uniform NFs having beads free and smooth surface with an average diameter in 50–200 nm range. The thermal stability of the NFs was increased by increasing the HNC concentration. The antimicrobial activity was examined against Escherichia
coli and staphylococcus strains and the NFs revealed auspicious antimicrobial potential. The drug release was studied at pH 7.4 (in PBS) at 37 °C. The drug release analysis showed that 90% of the drug was released from NFs in 2 h and 40 min. Hence, the prepared NFs could be used as a potential drug carrier and release in a control manner for biomedical application.
Publisher
Walter de Gruyter GmbH
Subject
Physical and Theoretical Chemistry
Reference57 articles.
1. Shaheen, M., Bhatti, I. A., Ashar, A., Mohsin, M., Nisar, J., Almoneef, M. M., Iqbal, M. Z. Phys. Chem. 2021, 235, 1395, https://doi.org/10.1515/zpch-2020-1741. 2. Samarth, N. B., Kamble, V., Mahanwar, P., Rane, A., Abitha, V. Chem. Int. 2015, 4, 202. 3. Majid, F., Shahin, A., Ata, S., Bibi, I., Malik, A., Ali, A., Laref, A., Iqbal, M., Nazir, A. Z. Phys. Chem. 2021, 235, 1279, https://doi.org/10.1515/zpch-2020-1751. 4. Nisar, J., Iqbal, M., Iqbal, M., Shah, A., Akhter, M. S., Khan, R. A., Uddin, I., Shah, L. A., Khan, M. S. Z. Phys. Chem. 2020, 234, 117; https://doi.org/10.1515/zpch-2018-1273. 5. Boukhouya, I., Bakouri, H., Abdelmalek, I., Amrane, M., Guemra, K. Chem. Int. 2018, 4, 120–129.
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