Affiliation:
1. Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
Abstract
A one-step synthesis of [1,6]naphthyridine-2(1H)-thione (3a), pyrano[3,4-b]pyridine-2(1H)- thione (3b), thiopyrano[3,4-b]pyridine-2(1H)-thione (3c) and 6-oxoquinoline-2(1H)-thione (3d) through the reaction of benzylidene-cyanothioacetamide (1) with cyclic ketones 2a−d is described. The reaction of 3a−d with organyl chlorides yielded the 2-alkylthio-3-cyanopyridines 4a−p which upon refluxing in ethanolic sodium ethoxide afforded the thieno[2,3-b]pyridine derivatives 5a−n. Some of the synthesized compounds were screened for the activity against bacteria and fungi.
Cited by
6 articles.
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1. Ultra-trace level colorimetric composite sensor based on novel DH-1,6-NAPY-8-CN-AgNPs for the detection of Clonazepam in aqueous and human plasma samples;Journal of Industrial and Engineering Chemistry;2023-09
2. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines;Topics in Current Chemistry;2021-02-24
3. Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives;Chemistry Central Journal;2017-11-02
4. Azido–tetrazole tautomerism of pyrano[3,4-c]pyridine derivatives;Russian Journal of Organic Chemistry;2017-06
5. Synthesis of derivatives of pyrano[3,4-c][1,2,4]triazolo-[4,3-a]pyridine and 8-(pyrazol-1-yl)pyrano[3,4-c]pyridine through pyridine ring rearrangement;Chemistry of Heterocyclic Compounds;2016-12