Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects-Reference-Cited by-同舟云学术

Indole Alkaloids from Aspidosperma rigidum and A. schultesii and their Antiparasitic Effects

Published:2011-06-01 Issue:5-6 Volume:66 Page:225-234
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Reina Matías¹,Ruiz-Mesia Wilfredo¹,Ruiz-Mesia Lastenia²,Martínez-Díaz Rafael³,González-Coloma Azucena⁴

Affiliation:

1. Instituto de Productos Naturales y Agrobiología (IPNA), CSIC, Avda. Astrofísico F. Sánchez 3, P. O. Box 195, 38206 – La Laguna, Tenerife, Canary Islands, Spain

2. Laboratorio de Productos Naturales Antiparasitarios de la Amazonía Peruana (LIPNAA), Universidad Nacional de la Amazonia Peruana (UNAP), Iquitos, Perú

3. Departamento de Medicina Preventiva, Salud Pública y Microbiología, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Madrid, Spain

4. Instituto de Ciencias Agrarias (ICA), CSIC, Serrano 115-dpdo, 28006 Madrid, Spain

Abstract

Five oxindole alkaloids, three plumerane-type alkaloids, subtype haplophitine, and one aspidospermatane-type alkaloid, subtype tubotaiwine, were isolated from the medicinal plants Aspidosperma rigidum and A. schultesii. One compound was identified as the transoid conformer of 18-oxo-O-methylaspidoalbine which was not previously described. The antiparasitic activity of all compounds against Trypanosoma cruzi and Leishmania infantum and their non-specific cytotoxicity against mammalian cells were also determined.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2011-5-605/pdf

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